Symptoms and signs of mesothelioma

Signs and symptoms of Mesothelioma - Mesothelioma is a cancer that develops in the mesothelium of the body, on the other side of the mesothelium serves as a protective covering for the body. It covers various organs, including lungs. mesothelium consists of two thin layers. That is why it is difficult to diagnose mesothelioma in early stages.

Until now, mesothelioma is still difficult to treat. Once the diagnosis of mesothelioma was made, the majority of patients will not live longer than eighteen months. There are various reasons for this, including the nature of disease after being diagnosed and the lack of an effective surgical method to remove the tumor.

While most cases of mesothelioma occur around the lungs, can also occur in the abdominal mesothelium, called the peritoneum, or pericardium. While mesothelioma is most common in the lungs, it is important to distinguish between mesothelioma and lung cancer. They are two very different types of cancer and requires different types of treatment are different.

Mesothelioma signs and symptoms may not appear until 20 to 50 years (or more) after exposure to asbestos. Shortness of breath, cough, and pain in the chest due to an accumulation of fluid in the pleural space (pleural effusion) are often symptoms of pleural mesothelioma.

Signs and symptoms of peritoneal mesothelioma include weight loss and cachexia, abdominal swelling and pain due to ascites (accumulation of fluid in the abdominal cavity). Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, difficulty swallowing, or swelling of the neck or face.

These symptoms may be caused by mesothelioma or by other, less serious conditions.

As for the signs and symptoms of Mesothelioma that affects the pleura as follows:

* Chest wall pain
* Pleural effusion, or fluid surrounding the lung
* Shortness of breath
* Fatigue or anemia
* Wheezing, hoarseness, or cough
* Blood in the sputum (fluid) cough (hemoptysis)

In severe cases, the person may have many tumor masses. Individuals can develop pneumothorax or lung collapse. This disease can spread to other parts of the body.

Tumors that affect the abdominal cavity often do not cause symptoms until they are at the final stage. Symptoms include:

* Abdominal pain
* Ascites, or an abnormal buildup of fluid in the abdomen
* Mass in abdomen
* Problems with intestinal function
* Weight

In cases of severe disease, the following signs and symptoms of Mesothelioma can be present:

* Blood clots in the veins, which may cause thrombophlebitis
* The spread intravascular coagulation, a disorder causing severe bleeding in many body organs
* Jaundice, or yellowing of the eyes and skin
* Low blood sugar levels
* Pleural effusion
* Pulmonary embolism, or blood clots in the arteries of the lungs
* Severe ascites

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Combination chemotherapy with cisplatin

Chemotherapy is one way of mesothelioma treatments that have been shown to improve survival in randomized and controlled trials. The study, published in 2003 by Vogelzang and colleagues compared cisplatin alone with combination chemotherapy of cisplatin and pemetrexed (brand name Alimta) chemotherapy) in patients not receiving chemotherapy for malignant pleural mesothelioma previously and are not candidates for more aggressive "curative" operation. This experiment is the first reported survival benefit of chemotherapy in malignant pleural mesothelioma, showed statistically significant improvement in average survival of 10 months in patients treated with cisplatin alone to 13.3 months in the combination group of patients receiving pemetrexed supplementation with folate and vitamin B12.

Vitamin supplements given to most patients in the trial and related side-effects of pemetrexed was significantly smaller in patients who received pemetrexed when they also receive a daily folate 500mcg oral and intramuscular vitamin B12 1000mcg every 9 weeks compared with patients receiving pemetrexed without vitamin supplementation. Objective response rate increased from 20% in the cisplatin group to 46% in the combination of pemetrexed. Some side effects such as nausea and vomiting, stomatitis, and diarrhea are more common in the combination of pemetrexed group but only affects a minority of patients and the overall combination of pemetrexed and cisplatin was well tolerated when patients received vitamin supplements, good quality of life and pulmonary function tests improved in the combination of pemetrexed. In February 2004, the United States Food and Drug Administration approved pemetrexed for the treatment of malignant pleural mesothelioma. However, there are still unanswered questions about the optimal use of chemotherapy, including when to start treatment, and the optimal number of cycles to give.

Cisplatin in combination with raltitrexed has demonstrated an improvement in survival similar to that reported for pemetrexed in combination with cisplatin, but raltitrexed is no longer available commercially for this indication. For patients unable to tolerate pemetrexed, cisplatin in combination with gemcitabine or vinorelbine is an alternative, or vinorelbine alone, although survival benefit has not been shown for this drug. For patients who can not be used cisplatin, carboplatin can be substituted but non-random data that have shown lower response rates and high levels of haematological toxicity for carboplatin-based combinations, although the survival rates similar to patients receiving cisplatin.

In January 2009, the U.S. FDA approved the use of conventional therapies like surgery and in combination with radiation or chemotherapy in stage I or II Mesothelioma after research conducted by a national study by Duke University concluded an increase of nearly 50 points at the level of remission.

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Metformin role in adjuvant therapy of endometrial cancer

According to the results of in-vitro tests conducted in the UK as it is written in the Journal of Clinical Endocrinology and Metabolism at the issue in March 2011, Bee K. Tan, MBBS, PhD, MRCOG, MRCPS (Glasg), University of Warwick, Coventry, and colleagues metformin as an oral antidiabetic potential to play a role as adjuvant therapy in the management of endometrial cancer, in this case explained their reasons for doing research on this topic. "Insulin sensitizers, in particular, the biguanide metformin, is widely used in the management of women with polycystic ovary syndrome (PCOS). Metformin is not only beneficial for improving insulin resistance and hyperinsulinemia in PCOS women, but also used long term to boost ovulation and improve cycle regularity menstruation.

In addition to suppress glucose production in the liver, metformin has shown beneficial effects in various tissues, including adipose tissue, skeletal muscle, and vascular endothelial. Recently, these drugs also have been shown to inhibit breast cancer cell growth. Because women with insulin resistance will develop endometrial cancer, the researchers decided to use various tests to study the quality of laboratory invasive endometrial cancer cells (ECC-1) in human serum samples from a group of 21 women both before and after they get metformin (850 mg twice daily) for 6 months. The results were compared with control group participants.

The average age of women around 28 years. The Warwick researchers found that in vitro invasion of the real weakened by sera from women with PCOS after 6 months of metformin treatment (P <.01). In addition, cancer cells spread around 25% slower in the serum. Based on their evaluation of sera with various tests, the researchers say, "This effect appears to be associated with NF-B, MMP-2 / 9 and Akt and ERK1 / 2 signaling pathway is known as an important regulator of inflammation, tumor invasion and metastasis.

The author emphasizes the findings require further research with randomized controlled trials. "This is an interesting study because we've been looking for things that metformin can do that can help women with PCO" explains the researcher.

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Asbestos workers who smoke at high risk of mesothelioma

In the United States for each year, reaching 2,000 to 3,000 people died cause of mesothelioma, cancer of the lining of the lungs or stomach that developed from inhaling microscopic asbestos fibers. Asbestos also contribute thousands of additional deaths from lung cancer each year.

National Cancer Society reported that about one in seven people who suffer from asbestosis, a chronic scarring of the lungs caused by prolonged exposure to asbestos as a result, eventually develops into lung cancer. Inhalation of asbestos increases the chances of developing mesothelioma and lung cancer and non-malignant respiratory diseases such as asbestosis, according to cancer experts. The higher the exposure to asbestos, the higher the risk of lung cancer.

Researchers have identified a number of factors that contribute to cancer development for non-smokers. Asbestos workers who smoke are not facing a five-fold risk of lung cancer than other nonsmokers, according to an article in The New York Times.

Growing high risk for asbestos workers who smoke. Smokers who have been exposed to asbestos face much higher risk of lung cancer.

Asbestos has been used in thousands of products such as roof shingles, water pipes, brake linings and some products for motor vehicles. In recent decades, the use of asbestos has declined since the late 1970s, and more than 40 countries have banned the use of all forms of asbestos. Today, asbestos is restricted in the United States, but not prohibited. People can still be exposed during demolition or renovation of buildings containing asbestos or in the workplace who still use asbestos. Some jobs such as demolition workers, and plumbers have a high risk of exposure and possible higher risk of asbestos-related diseases.

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Mesothelioma Chemotherapy, Cisplatin and Carboplatin

A mesothelioma article recently published in scientific journals Lung Cancer that examined the benefits and costs with a combination of Cisplatin and Carboplatin and Pemetrexed Pemetrexed for mesothelioma chemotherapy.

PA Photo Asbestos Exposure Mesothelioma Chemotherapy combination of Cisplatin and Pemetrexed is one of several chemotherapy options that have proven successful enough to handle patients with malignant pleural mesothelioma / malignant pleural mesothelioma (MPM), but this combination can be very toxic to the body. There is no cure and treatments for malignant mesothelioma cancer without undesirable side effects.

In the journal the researchers noted that "there are two phases of a randomized study in Phase III shows the benefits for the prognosis of mesothelioma with the use of antifolates such as raltitrexed or pemetrexed, when combined with cisplatin. The study has shown an absolute improvement in overall survival an average of 2.6 and 2.8 months, compared with single treatment for cisplatin. This makes a lot of institutions using cisplatin and pemetrexed as the standard palliative chemotherapy treatment for malignant pleural mesothelioma. "

Unfortunately, the combination of cisplatin and pemetrexed produces unwanted toxic effects and it encourages researchers to study other chemotherapy drugs to be combined with pemetrexed. Researchers said, "Recently, two phase II trials have evaluated the efficacy of Carboplatin and pemetrexed in MPM. Both studies showed overall response rate of 18.6 and 25%, with a survival rate of 12.7 and an average of 14 months. Following on from these results, we have undertaken a retrospective analysis in patients with MPM treated with Carboplatin and Pemetrexed in our institution. "

In an effort to find a combination chemotherapy of mesothelioma with minimal toxicity and side effects, the researchers investigated further by replacing Cisplatin with Carboplatin when paired with Pemetrexed. Using a retrospective approach, researchers evaluated 49 cases of malignant pleural mesothelioma who were given a combination of Carboplatin and Pemetrexed and compare the results with data of cisplatin combination chemotherapy with Pemetrexed.

Level of disease control (known in the absence of progressive signs of mesothelioma over CT scan) for patients was 69 percent, and the percentage of partial response and stable disease by 28 percent and 41 percent. Clinical improvement is shown in figure 69 percent, the majority of patients reported an increase in profits after two cycles of chemotherapy. Toxicity is generally low and better than the toxicity of cisplatin with pemetrexed.

The average time to treatment failure was 4.6 months. The average overall survival in this study is 14 months, compared with the cisplatin-pemetrexed for 12.1 months. The authors suggested, "In conclusion, our data show a combination of Carboplatin and Pemetrexed may be an option in the treatment of mesothelioma, particularly in patients who experience problems with the use of cisplatin."

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People who are potentially affected by mesothelioma

 Mesothelioma is a disease of cancer that can be defined as a malignancy that occurs in the mesothelial layer. The mesothelium is the protective tissue that contained as a layer on the outer surface of the body's vital organs including the lungs, heart and stomach. There are three main types of mesothelioma in the human body that include epithelioid type, sarcomatoid type and mixed or biphasic type. Mesotheliomas also grouped based on the network or location. Mesothelioma Pleural mesothelioma is pleural tissue occurs in the lungs, while occurring in the abdomen called peritoneal mesothelioma peritoneum. Pericardial Mesothelioma occurs in the cavity around the heart and testes peritoneal Mesothelioma occurs in the testes.

The greatest thing that could be the cause of Mesothelioma is because of exposure to asbestos. According to studies, people who are employed as factory workers, miners, insulation manufacturers, railroad workers, ship builders, gas mask factory and construction workers is the highest potential for Mesothelioma. These employees can file a lawsuit against the company if the company values ​​profits over human life. Typically, companies do not implement prevention technologies is important and tends to ignore the adverse effects of hazardous chemicals to employees. In this situation, the only way to get justice if diagnosed with mesothelioma is to file a lawsuit. A successful lawsuit could provide a means of financial security for families and also pay the expenses incurred on medical treatment.

Mesothelioma diagnosis is difficult because most of the symptoms are similar to various other diseases. Pleural Mesothelioma symptoms were found during the respiratory disease including chest and back pain, difficulty swallowing, respiratory distress, persistent cough, fever, nausea and weight loss. Peritoneal Mesothelioma symptoms include abdominal swelling, loss of appetite, abdominal pain, swollen feet, stomach and vomiting does not irregular.

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Effectiveness of chemotherapy and its effects

Chemotherapy is a cancer treatment in the medical use of drugs to treat various types of cancer. Ordinary given before or after surgery. The goal of chemotherapy is to eradicate all the cancer cells get to the roots, up to a location that is not affordable scalpel and least able to control the cancer cells so as not to spread more widely.

Two main reasons Chemotherapy is often done to control or eliminate the tumor to relieve cancer symptoms such as pain. This type of chemotherapy is called palliative chemotherapy.

While chemotherapy does any other purpose is to prevent the reappearance of cancer cells after surgery or radiation therapy to control tumor.

This type of chemotherapy is called adjuvant chemotherapy. The way the chemotherapy is working with the target and eliminate cancer cells that grow very rapidly in the body.

Basically, the treatment of cancer depends on the type or types of cancer and where the cancer. Age, general health condition of patients and treatment system also affects the process of cancer treatment. In the case of cancer, the main treatment is through:

    Surgery or Surgery
    Chemotherapy or by giving drugs
    Beam radiotherapy or Use of Radiation

But in fact, will typically use more than one way of treatment. For instance surgery followed by chemotherapy or radiotherapy, and sometimes treatment must be done by using the 3 combination.

Basically the main goal of surgery is to remove the cancer as a whole because the cancer can be cured only if it has not spread to other places. While chemotherapy and radiation intended to kill cancer cells or stop the growth of cancer cells that are still left behind.

Chemotherapy is a treatment process by using medications aimed at killing or slowing the growth of cancer cells. Chemotherapy drugs are usually administered intravenously or orally. The frequency and duration of chemotherapy depends on the type of cancer, stage, other health problems, types of chemotherapy drugs are prescribed, and other methods of treatment used.

Are There Side Effects of Chemotherapy?
Depending on the type, chemotherapy is given every day, once a week, three weeks, even once a month. How many series of patients have to undergo chemotherapy, also depending on the type of cancer sufferers. The most feared side effects of chemotherapy is. Side effects of chemotherapy depend on many things, among other types of chemotherapy drugs, the condition of your body, your mental condition, and so on.

Chemotherapy side effects occur because chemotherapy drugs are very powerful, and kill not only cancer cells, but also attack healthy cells, especially cells that divide rapidly. Therefore the side effects of chemotherapy appear on parts of the body that his cells are rapidly dividing. Side effects can arise when doing the treatment or some time after treatment. Side effects that may arise is, among others:

    The body felt weak
    This is a common side effect is found, the onset can be sudden or slow. Sometimes it can continue until the end of treatment, and does not disappear simply by resting.
    Nausea and vomiting
    There are several chemotherapy drugs are more make nausea and vomiting. In addition there are some people who are very prone to nausea and vomiting. This can be prevented by a given anti-nausea drugs before, during, or after chemotherapy treatment.
    Indigestion
    Some types of chemotherapy drugs have an effect diarrhea. There's even a diarrhea accompanied by severe dehydration should be treated. Constipation can sometimes occur. If diarrhea: subtract fiber foods, cereals, fruits and vegetables. Drink plenty to replace lost fluids.
    Sprue and affect sense of taste
    Some chemotherapy drugs cause mouth diseases such as thick or infection. Chemotherapy can also damage taste receptors in the mouth. Changes in sense of taste is usually started a week after the chemotherapy began and lasted for 3-4 weeks.
    Hair loss
    Hair loss is temporary, usually two or three weeks after chemotherapy begins. Can also cause hair breakage near the scalp. Can occur after several weeks of therapy. Hair can grow back after chemotherapy is completed.
    Muscle and nerve disorders
    Some chemotherapy drugs cause tingling and numbness in the fingers or toes, and weakness in leg muscles.
    Effects on blood
    Some types of chemotherapy drugs can affect the bone marrow of work which is the manufacturer of the blood cells, thereby decreasing the number of blood cells. The most frequent is a decrease in white blood cells (leukocytes). Decrease in blood cells occur in every chemotherapy and blood tests will be carried out before the next chemotherapy to ensure blood cell count has returned to normal. Decrease in the number of blood cells can lead to infections, bleeding, and anemia.
    The skin can become dry and discolored
    More sensitive to the sun. Nails grow more slowly and there are white lines across.
    Hormone production is not stable
    Lowered libido and affect fertility in both men and women.

Some dietary supplement products claim to reduce the side effects of chemotherapy as well as rebuild the condition of your body. You can use it, but please check with an expert, and certainly with your doctor as well.

Adopted from www.deherba.com

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Factors causing gestational trophoblastic

Some risk factors that can trigger the occurrence of gestational trophoblastic disease has been identified, but how each of these factors are interrelated and influence each other is still not clearly known. Here are a risk factor for gestational trophoblastic disease (MTD).

In women with age <15 years and> 40 years had the greatest risk and increased significantly in women who have had previous PTG is 20-40 times higher than women in general. Once an MTD, the risk for subsequent molar pregnancy is 0.6 to 3%.

One study reported increased risk of recurrent PTG in women of India and Pakistan who live in the UK by 2.4-fold compared with the general population. Multiple pregnancy and artificial insemination also been reported to increase the risk of sunfish. In general, the risk of PTG is more common in ethnic Asian, African, and Central America.

The occurrence of cases is familial recurrent PTG has been reported. This marks that there is a genetic basis for the PTG. Studies have found a gene defect on chromosome 13q13, four named NLRP7, which is part of a gene family CATERPILLAR. NLRP7 may play a role in oogenesis or endometrium during trophoblast invasion and formation of a layer of decidua.

Although some studies have found no association between the risk of PTG and regional groups ABO, affected women more PTG with blood type B. Other factors include cigarette consumption, use of oral contraceptives, certain herbicides (agent orange), and radiation.
Prevention What can I do?

Ethnic and genetic risk factors simply can not be changed while the environmental risk factors are most easily converted yet found a definite association with the occurrence of gestational trophoblastic disease. This causes its own difficulties in doing primary prevention in pregnant women. Primary prevention is limited to the recommendation for pregnant between ages 15-30 years, to avoid pregnancy outside of that age, and avoiding pregnancy.

In secondary prevention, more emphasis on early detection and treatment in accordance with applicable guidelines. It is based on a high cure rate for patients with malignant trophoblastic disease. Although there are already metastatic, if the disease is detected and treated quickly then the recovery rate will be higher.

The main cause of poor prognosis are the delay in diagnosis and therapy. Treatment of gestational trophoblastic disease with low risk is through a single chemotherapy, whereas in patients with malignant trophoblastic disease are given chemotherapy combinations.

Last step is prevention tertiary prevention. At this stage, more emphasis on rehabilitation. Generally, patients with gestational trophoblastic disease successfully treated with suction curettage for hydatidiform mole, and chemotherapy for a malignant trophoblastic diseases such as choriocarcinoma. Meanwhile, hysterectomy (removal of uterus) only option for those who do not want to maintain reproductive function.

adopted from www.deherba.com

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Trigger factors of ovarian cancer

In addition to genetic factors there were four other factors that influence the risk of ovarian cancer that reproductive factors, hormonal factors, and environmental factors. To take precautions, then we need to know the trigger factors that can increase the risk of ovarian cancer.

The biggest impact on this disease caused by the reproductive history (pregnancy, childbirth) and the duration and distance of reproduction, low parity (number of low birth) and infertility (sterility), menars (first got menstrual) early and late menopause increase the risk for developing ovarian cancer.

Multiple pregnancies (twins) can enhance the protective effect against the development of ovarian cancer.

The combination of ibuprofen and famotidine in NSAID therapy

A phase-3 study, Reduce (Registration Endoscopic Study to Determine Ulcer Formation) performed by dr. Michael Weinblatt and colleagues from Brigham and Women's Hospital in Boston, Massachusetts, United States, giving the conclusion that the therapeutic use of preparations containing a combination of ibuprofen plus famotidine may decrease the side effects of upper GI in patients who memerlukkan therapy with NSAID class of drugs (Nonsteroidal antiinflammatory Drugs). The results of this study have been presented at the annual meeting of the American College of Rheumatology.

Therapeutic use of NSAIDs in these patients effectively manage pain in patients. However, administration of NSAIDs can damage the gastrointestinal mucosa, especially in the stomach and upper small intestine. Whereas in the United States, approximately 43 million sufferers of osteoarthritis and rematoidartritis routinely treated with NSAIDs. Damage to the mucosa can lead to the onset of ulcers and gastrointestinal bleeding. Approximately 30% of patients treated with NSAIDs will have gastrointestinal side effects, and on more than

Increased EPC as a result of Citicoline with r-TPA

In patients with acute ischemic stroke increases in circulating endothelial progenitor cells (EPCs) is associated with better outcomes. CDP-choline (citicoline) enhance brain plasticity after stroke. This was revealed from the results of citicoline supplementation study conducted by Sobrino T, et al, published in Research in 2011 Neurolgical this.

Researchers define the EPC increase during the first week as the difference in the number of CFU-EC between day 7 and at the start of treatment. This is obtained by performing the study forty-eight patients with non-lacunar ischemic stroke is the first row is included in the study within 12 hours after the first attack. Patients received treatment with citicoline 2000 mg / day (n = 26) or received no treatment (placebo)

Clopidogrel efficacy of antiplatelet

Based on the results of research conducted by dr. Pamela Moceri MD and colleagues from the Cardiology Department, Pasteur University Hospital of Nice, Nice, France, can be concluded that the decrease in effectiveness of clopidogrel because of clopidogrel in conjunction with the PPI can be overcome by increasing the dose of clopidogrel to 2-fold, or replace the PPI with ranitidine.

Apparently from the results of this study increased attention to interactions that may occur and decrease the effectiveness of antiplatelet agent clopidogrel. In 2009, the FDA (Food and Drug Administration) warnings regarding the concurrent administration of clopidogrel with omeprazole. In his warning, the FDA also stated that patients with high risk of heart attacks and strokes are treated with clopidogrel will not gain the full benefit of clopidogrel when administered together with omeprazole. FDA at that time recommend changes to the label clopidogrel with a new celebration, the interaction of clopidogrel with omeprazole and other drugs that inhibit the enzyme CYP2C19. Patients who were treated using clopidogrel and require medications that reduce stomach acid is recommended to be treated using H2 antagonists such as ranitidine or famotidine, because the FDA has confidence that these drugs do not interact with clopidogrel. While drugs are not recommended in conjunction with clopidogrel dosing among others such as cimetidine, fluconazole, ketoconazole, voriconazole, etravirine, felbamate, fluoxetine, fluvoxamine, and ticlopidine.

Clopidogrel has been used extensively to overcome aterotrombotik events, both in patients with cardiovascular events, cerebrovascular, and peripheral arterial disease, as well as in patients with high cardiovascular risk. In studies such as CAPRIE, CURE, CLARITY-TIMI well as other research, the

Clash of the head trigger stroke

For adults who get a clash of heads (TBI-Traumatic Brain Injury) which in the long term will increase the risk of having a stroke, especially in the first 3 months after injury, this was the conclusion of a study conducted by Herng-Ching Lin, PhD , and colleagues from Taipei Medical University in Taiwan and published online in the journal Stroke in July 2011. In his article, Herng-Ching Lin, PhD, and colleagues from Taipei Medical University, argues that it is only natural to speculate that the occurrence of cerebrovascular damage in the head caused by TBI may lead to hemorrhagic or ischemic stroke. Despite the evidence that relationship is still a little, one in the study.

Dr Tim. Lin uses a database of national insurance Taiwan to analyze 23 199 TBI patients and compared with 69,597 non-TBI patients. The average age of subjects was 42 years old, and 54% were male. Each individual was followed for 5 years. In the first 3 months after TBI, stroke occurred in 675 patients with TBI (2.9%) vs. 207 non-TBI patients (0.30%). Over the past 5 years, patients experiencing a TBI 1901 (8.2%) experienced a stroke compared with 2710 non-TBI patients (3.9%).

After adjusting for sociodemographic characteristics and comorbidities are selected, TBI was independently associated with an increased risk of stroke more than 10-fold in the first 3 months after injury and increased risk of more than 4-fold to 1 year after injury. Even at 5 years, TBI patients have a risk about 2-fold increased relative stroke for non-TBI population.

Dr. Lim, et al. based on the study concluded that stroke is one of the neurological problems that may increase risk after a clash of heads (TBI).

Adopted from www.topnews.in

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Tips inflamed gums

Everyone must have experienced swelling of the gums. In addition to swelling, inflammation of the gums or gingivitis also causes pain that is very disturbing. Swelling of the gums common in pregnant women or due to side effects of certain medicines.

Here are some tips to cope with the swollen gums:

•     Avoid inflamed gums from materials that are irritating materials such as cigarettes, a liquid  mouthwash or alcohol.
•     Eat a balanced and nutritious.
•     Use of other brands of toothpaste if you use toothpaste that has been causing irritate the gums.
•     Perform routine dental care every six months to the dentist.
•     When swollen gums are caused by medication, consult your doctor to ask a doctor to replace with another drug.
•     If swollen gums and disrupt longstanding food intake, get to the dentist.

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The risk of atherosclerosis if less vitamin D

A study from the Northern Manhattan Study has found new evidence regarding the relationship of low vitamin D levels with the incidence of atherosclerosis. Their results show that levels of 25-hydroxyvitamin D levels will increase hardening of the intima-media thickness and carotid plaque as a result. It is delivered by a senior researcher Dr. Shonni Silverberg, from the Columbia University College of Physicians and Surgeons, New York, published in the journal Stroke in August 2011.

They also found that 25-hydroxyvitamin D was inversely with intima media thickness (beta, -0.01 per increase 10-ng/mL; P = 0.05) and carotid plaque thickness (beta, -0.10 increase per 10 - ng / mL, P = 0.03). In the model containing risk factors for heart disease and an index of mineral metabolism, 25-hydroxyvitamin D

Potential birth defects due to pollutants

Women who smoke during pregnancy appear to coal and pesticides has achieved four times more likely to give birth in a nervous tube defects (NTD), it is based on a study done in China. The researchers studied on 80 newborns and aborted fetuses with defects of the brain and spinal cord defects in the placenta and they clearly have a much higher amount of certain chemicals than babies without birth defects placenta.

Birth defects has long been associated with folic acid deficiency, maternal obesity and diabetes. Environment pollution has also been suspected as a cause of others, but as yet there is very little direct evidence to show that relationship.

In research in China, researchers detected a polisiklik aromatic hydrocarbons (PAH), high levels of inhaling

GnRH agonist therapy and premature ovarian failure

In young women who develop breast cancer, ovarian suppression while using triptorelin, a gonadotropin-releasing hormone analog, during the process of chemotherapy proved to reduce the incidence of premature menopause. These findings have been published in the Journal of the American Medical Association in July 2011 and is the result of a study in Italy.

The team of researchers from the Instituto Nazionale per la Ricerca sul Cancro, Genoa, headed by dr. Lucia Del Mastro, underlined that about 6% of women diagnosed with breast cancer under the age of 40 years, and mostly treated with chemotherapy or hormonal therapy. So far, there has been no standard therapies are applied to prevent the occurrence of premature ovarian failure. To investigate the protective effects of temporary ovarian suppression during the treatment of breast cancer, the researchers recruited 281

Correlation of liver cancer and metabolic syndrome

The risk of heart disease and diabetes could be improved, as evidenced by the risk factors of metabolic syndrome, and it also seems related to the incidence of liver cancer. Results from a large-scale study found that metabolic syndrome is associated with increased risk of developing hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).

The researchers found that metabolic syndrome was significantly more common in people who developed it revealed the results of the exposure data in the event the annual scientific meeting of the American Association for Cancer Research (AACR). Data changes that happen to be HCC (37.1%) and ICC (29.7%) than in the comparison group (17.1%, P <.0001). Even after multiple logistic regression analysis, metabolic syndrome

Morphine sparing effect By Paracetamol

Acetaminophen or that we are familiar with Paracetamol is an analgesic antipyretic drug that is used to relieve pain and reduce fever. As an analgesic, paracetamol works by increasing the excitatory threshold of pain and as an antipyretic, suspected of working directly on the heat regulating center in the hypothalamus. Based on the guidelines of the WHO analgesic administration, in this case paracetamol, can be used on mild pain or moderate to severe pain when combined with opioid analgesics. Use of paracetamol in conjunction with opioid class of analgesics (morphine) can not only improve the effectiveness of analgesics but also can decrease the need for analgesic opioids (morphine) in moderate to severe pain, known by the name of the morphine sparing effect. Decline in demand is expected to decrease opioid side effects from the use of opioid analgesics group.

Meta-analysis by Remy et al (2005) conducted on seven prospective randomized studies with comparison, the number of patients with post-operative 265 in group acetaminophen (oral or intravenous) + morphine and 226 patients with morphine alone, showed that administration of acetaminophen reduces the need morphine (morphine sparing effect) by 20% (Average -9 mg; CI -15 to -3 mg, p <0.003). However, the results of this meta-analysis found no reduction in incidence of side effects of morphine morphine although demand has decreased.

In contrast to the results of a meta-analysis has been performed by Remy et al, the study by Young et al. (2011) of 76 women who underwent hysterectomy were randomly get 2 grams of intravenous premedication

Gastroesophageal reflux disease (GERD) due to lifestyles and environments

Gastroesophageal reflux disease (GERD) is a combination of spectrum-related disorders, including hiatal hernia, reflux disease with associated symptoms, erosive esophagitis, peptic strictures, Barrett esophagus, and esophageal adenocarcinoma. In addition to several pathophysiology and the relationship between some of these disorders, GERD is also characterized by the occurrence of identical co-morbidities and by the epidemiological behavior of similar patients.

Environmental risk factors in the etiology of GERD disease showed a marked and formed from temporal and geographical variations. Also variation by time, geography and race. Between 1975 and 2005, the incidence of GERD and esophageal adenocarcinoma has increased five-fold in most Western countries. The incidence

Savor the fruit soursop for cancer

Soursop or also known as the Soursop. In addition to delicious, this fruit is also rich in drug content.
Efficacy of soursop fruit gives effect anti-tumor / cancer is very strong, and medically proven to cure all kinds kanker.Selain cure cancer, soursop fruit also acts as an anti-bacterial, anti fungi (fungi), effektive against various types of parasites / worms, lowering high blood pressure, depression, stress, and normalize the nervous system that are less good.

It was a sweet acidity that provides sensation for the fans. For those who like breakfast with bread, fruit soursop are also often added in the form of jam. Whatever the form of processed products, the taste of soursop remains strongly attached to the product, making it very easy to recognize.

The content of soursop fruit is as follows:
Rich in Vitamin C
Soursop fruit consists of 67.5 percent pulp, 20 percent of the fruit peel, fruit seeds 8.5 percent and 4 percent of the fruit core.
After water, the highest content of nutrients in the soursop is carbohydrates. One type of carbohydrate in the soursop fruit is a reducing sugar (glucose and fructose) with levels of 81.9 to 93.6 percent of the total sugar content.
Soursop fruit contains very little fat (0.3 g/100 g), so it is good for health. Sour taste in soursop derived from non-volatile organic acids, particularly malic acid, citric acid, and acid isositrat.
Vitamins are the most dominant in the soursop fruit is vitamin C, which is about 20 mg per 100 grams of fruit

Honey and usefulness

Honey is food containing various nutrients such as carbohydrates, proteins, amino acids, vitamins, minerals, dextrin, plant pigments and Aromatic components. Even from the results of expert research Nutrition and food, honey contains a carbohydrate which is highest among other livestock products are milk, eggs, meat, cheese and menterga approximately (82.3% higher) Every 100 grams of pure honey is worth 294 calories or the ratio of 1000 grams of honey pure equivalent to 50 chicken eggs or 5.675 liters of milk or 1680 grams of meat. From the results of a recent study found the substances or compounds that are in honey is very complex, which reached 181 species.

Usefulness of honey has been known since the days of Ancient Egypt. Even Queen Cleopatra has used to maintain health and beauty.
It is also used honey for embalming herb (Embalming) to preserve the mummy of ancient Egyptian kings.
Japanese tradition is to drink honey every night to wake up in a state of fresh and healthy.

One of the unique honey is because honey contains antibiotic substances. This was the result of research Peter C Molan (1992), researchers from the Department of Biological Sciences, University of Waikoto, New Zealand. According to Honey proved to contain antibiotic substances active against attack various pathogens that cause disease.

In addition, researchers from the Department of Biochemistry, Faculty of Medicine, University of Malaya in Malaysia, Kamaruddin (1997) also mentions that in the honey contains anti-microbial substances, which can inhibit the disease.

Some infectious diseases by various pathogens that can be prevented and cured by drinking the honey on a regular basis include: upper respiratory tract infections (ARI), cough, fever, wound ulcer disease, gastrointestinal infections, skin diseases.