Thursday, August 4, 2011

Increased EPC as a result of Citicoline with r-TPA

In patients with acute ischemic stroke increases in circulating endothelial progenitor cells (EPCs) is associated with better outcomes. CDP-choline (citicoline) enhance brain plasticity after stroke. This was revealed from the results of citicoline supplementation study conducted by Sobrino T, et al, published in Research in 2011 Neurolgical this.

Researchers define the EPC increase during the first week as the difference in the number of CFU-EC between day 7 and at the start of treatment. This is obtained by performing the study forty-eight patients with non-lacunar ischemic stroke is the first row is included in the study within 12 hours after the first attack. Patients received treatment with citicoline 2000 mg / day (n = 26) or received no treatment (placebo)
(n = 22) for the acute phase of ischemic stroke for 6 weeks. EPC colonies counted as colony forming unit-endothelial cell (CFU-EC) early at the start of treatment and on day 7.


Patients treated with citicoline and perform the treatment on recombinant tissue-plasminogen activator (r-TPA) showed a greater increase in EPC as compared with patients only treated with citicoline or untreated (35.4 + 15.9 + 8.4 versus 8.1 versus 10.2 + 0.9 CFU-EC, P <0.0001). In fact CFU-EC at the beginning of the same treatment in each patient in the citicoline treatment groups and non-treatment group (7.7 + 7.3 CFU-EC, p = 0.819). In logistic models, citicoline treatment [odds ratio (OR), 17.6; confidence interval (CI) 95% v 2.3 to 137.5, P = 0.006] and concurrent treatment with citicoline and r-tPA (OR, 108 , 5; 95% CI 2.9 to 1094.2, P = 0.001) independently associated with increased EPC> 4 CFU-EC.

From the conclusions in the study showed that administration of citicoline and citicoline in conjunction with r-TPA can increase the concentration of EPC in acute ischemic stroke.

Adopted from www.polycystic-ovarian.blogspot.com


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