Tuesday, June 28, 2011

Cefixime is more effective than ciprofloxacin for Urinary Tract Infection Women without complications

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Cefixime is more effective and safer than ciprofloxacin for women with uncomplicated urinary tract infections, this is the result of research presented in the 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). In his research Dr. Evgeny Dovgan from the Department of Clinical Pharmacology, Smolensk State Medical Academy, Smolensk, Russia, mentioning that this study aims to compare the efficacy and safety of cefixime and ciprofloxacin antibiotic use short-term (5 days) for the treatment of female urinary tract infection without complications.

Of the total of 104 premenopausal women with symptoms of uncomplicated urinary tract infections were randomly assigned to cefixime 400 mg once daily for 5 days or ciprofloxacin 250 mg/500 mg obtain twice
daily for 5 days. Further evaluation of patients on days 3 and 5 (2nd visit) and the 28th day after treatment is completed (visit 3). From kunjugan to-2, patients who received cefixime showed significantly greater eradication occurred when compared with patients receiving the ciprofloxacin respectively (95.9% vs. 66.0%, P =. 0002), which continued until day-28 (94.7% vs. 75.9%, P =. 026). There is also a tendency that cefixime is better than ciprofloxacin in terms of cure rate is masng amounted to (75.5% vs. 58.1%, P =. 07), and clinical improvement of patients that is equal to (93.9% vs. 81.1%, P =. 06 ).

Recurrence rate was not significantly different between the 2 groups (13.2% vs. 19.4%, P =. 49). However, the failure rate is higher for patients receiving ciprofloxacin compared with patients receiving cefixime (6.1% vs. 18.9%, P =. 06). in terms of side effects, the most common adverse events (AEs) in the cefixime group were bacterial vaginosis (n = 2), and ciprofloxacin are were diarrhea (n = 7), bacterial vaginosis (n = 2), urticaria (n = 1 ), and pyelonephritis (n = 1).
Cefixime is more effective and safer than ciprofloxacin for women with uncomplicated urinary tract infections, this is the result of research presented in the 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). In his research Dr. Evgeny Dovgan from the Department of Clinical Pharmacology, Smolensk State Medical Academy, Smolensk, Russia, mentioning that this study aims to compare the efficacy and safety of cefixime and ciprofloxacin antibiotic use short-term (5 days) for the treatment of female urinary tract infection without complications.

Of the total of 104 premenopausal women with symptoms of uncomplicated urinary tract infections were randomly assigned to cefixime 400 mg once daily for 5 days or ciprofloxacin 250 mg/500 mg obtain twice daily for 5 days. Further evaluation of patients on days 3 and 5 (2nd visit) and the 28th day after treatment is completed (visit 3). From kunjugan to-2, patients who received cefixime showed significantly greater eradication occurred when compared with patients receiving the ciprofloxacin respectively (95.9% vs. 66.0%, P =. 0002), which continued until day-28 (94.7% vs. 75.9%, P =. 026). There is also a tendency that cefixime is better than ciprofloxacin in terms of cure rate is masng amounted to (75.5% vs. 58.1%, P =. 07), and clinical improvement of patients that is equal to (93.9% vs. 81.1%, P =. 06 ).

Recurrence rate was not significantly different between the 2 groups (13.2% vs. 19.4%, P =. 49). However, the failure rate is higher for patients receiving ciprofloxacin compared with patients receiving cefixime (6.1% vs. 18.9%, P =. 06). in terms of side effects, the most common adverse events (AEs) in the cefixime group were bacterial vaginosis (n = 2), and ciprofloxacin are were diarrhea (n = 7), bacterial vaginosis (n = 2), urticaria (n = 1 ), and pyelonephritis (n = 1).

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