Factors causing gestational trophoblastic

Some risk factors that can trigger the occurrence of gestational trophoblastic disease has been identified, but how each of these factors are interrelated and influence each other is still not clearly known. Here are a risk factor for gestational trophoblastic disease (MTD).

In women with age <15 years and> 40 years had the greatest risk and increased significantly in women who have had previous PTG is 20-40 times higher than women in general. Once an MTD, the risk for subsequent molar pregnancy is 0.6 to 3%.

One study reported increased risk of recurrent PTG in women of India and Pakistan who live in the UK by 2.4-fold compared with the general population. Multiple pregnancy and artificial insemination also been reported to increase the risk of sunfish. In general, the risk of PTG is more common in ethnic Asian, African, and Central America.

The occurrence of cases is familial recurrent PTG has been reported. This marks that there is a genetic basis for the PTG. Studies have found a gene defect on chromosome 13q13, four named NLRP7, which is part of a gene family CATERPILLAR. NLRP7 may play a role in oogenesis or endometrium during trophoblast invasion and formation of a layer of decidua.

Although some studies have found no association between the risk of PTG and regional groups ABO, affected women more PTG with blood type B. Other factors include cigarette consumption, use of oral contraceptives, certain herbicides (agent orange), and radiation.
Prevention What can I do?

Ethnic and genetic risk factors simply can not be changed while the environmental risk factors are most easily converted yet found a definite association with the occurrence of gestational trophoblastic disease. This causes its own difficulties in doing primary prevention in pregnant women. Primary prevention is limited to the recommendation for pregnant between ages 15-30 years, to avoid pregnancy outside of that age, and avoiding pregnancy.

In secondary prevention, more emphasis on early detection and treatment in accordance with applicable guidelines. It is based on a high cure rate for patients with malignant trophoblastic disease. Although there are already metastatic, if the disease is detected and treated quickly then the recovery rate will be higher.

The main cause of poor prognosis are the delay in diagnosis and therapy. Treatment of gestational trophoblastic disease with low risk is through a single chemotherapy, whereas in patients with malignant trophoblastic disease are given chemotherapy combinations.

Last step is prevention tertiary prevention. At this stage, more emphasis on rehabilitation. Generally, patients with gestational trophoblastic disease successfully treated with suction curettage for hydatidiform mole, and chemotherapy for a malignant trophoblastic diseases such as choriocarcinoma. Meanwhile, hysterectomy (removal of uterus) only option for those who do not want to maintain reproductive function.

adopted from www.deherba.com

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