The use of statins was not associated with an increased risk of cancer. This is based on the results of retrospective analysis conducted by dr. Claudio Marelli et al. of S2 Statistical Solutions in Cincinnati, Ohio, United States, and has been published in the Journal of the American College of Cardiology July 2011 issue. While another study, conducted by Jenny Poyntern et al. from the Departments of Epidemiology University of Michigan, United States, showed that statin use is accompanied with a reduction in relative risk of colorectal cancer by 47%. There is also another study, conducted by dr. Elizabeth Platz et al. from the Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, showed that administration of statins is not associated with risk of prostate cancer and even reduce the risk of prostate cancer. Another study, conducted
by Dr Alawi Alsheikh-Ali and Richard Karas of Tufts University School of Medicine, Boston, United States, also found no association between increased cancer risk with statin use.
However, there are several other observational studies that showed that long-term statin administration may increase the risk of cancer. Research conducted by dr. Ilir Agalliu et al. of the Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States showed an increased risk of cancer in obese patients treated with statins. Another with the research by dr. Patricia Coogan Slone Epidemiology Center of Boston University School of Medicine, Boston. Research does not show a decreased risk of colorectal cancer in patients treated with statins. Given the numerous studies with contradictory results, the dr. Marelli et al. conduct a retrospective analysis to determine the effects of statin therapy on cancer risk.
Research conducted by dr. Marelli et al. It uses data from the General Electric Centricity data center, which is an EMR (electronic medical records) are widely used commercially by the doctors in the United States for the regulation of the medical records of more than 30 million patients. After doing a search using the method of score-propensitas, the researchers found 45,857 patients who fit the study criteria (statin users and non-statin) from 1990 to 2009. The results showed that after the follow-up, an average of 4.6 years, the incidence of cancer was not significantly different between the two treatment groups (statin users and non-statin).
In conclusion, retrospective study conducted showed no significant association between statin use with an increased risk of cancer. The results are consistent with several studies conducted earlier. In 2005, CTT (Cholesterol Treatment Trialists) published a meta-analysis of 14 randomized studies involving more than 90,000 patients and found no increased cancer risk with statin therapy. In 2010, once again CTT publish an up-date on the meta-analysis ever conveyed, which also found no association between statin therapy with an increased risk of cancer.
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