Comparative study conducted in Taiwan showed that silodosin improve symptoms of lower urinary tract symptoms (lower urinary tract symptoms, LUTS) that accompany benign prostate enlargement (benign prostatic hyperplasia, BPH) as well as tamsulosin, and even more rarely cause side effects hypotension. As tamsulosin, silodosin is a class of drugs inhibiting alpha-1A-selective adrenoceptors, but higher selectivity. This was revealed by dr. Hong-Jeng Yu and colleagues from the National Taiwan University Hospital, Taipei, published online in the BJU International in mid-May 2011.
To find out whether a high-receptor selectivity in silodosin actually provide clinical benefit, the research team carry out a randomized double-blind study comparing tamsulosin silodosin in 209 patients with BPH. In the study for 12 weeks, patients were divided into two groups. Silodosin The first group received 4 mg twice daily, while the second group received tamsulosin 0.2 mg once daily (according to recommended doses in
males Asia). The primary endpoint was change in score of the IPSS (International Prostate Symptom Score), compared with the score measured at baseline. Decrease in score by 25% or more was achieved by 86.2% of patients silodosin group and 81.9% of patients tamsulosin group (p = 0.53). The difference in change in IPSS scores between the two groups is 0.60, in the non-inferiority limit of 1.0. Secondary endpoint, namely the rate of emission maximum urine and health-related quality of life, also equivalent between the two groups.
Systolic blood pressure decreased on average by 4.2 mm Hg with tamsulosin, but only 0.1 mm Hg with silodosin. The researchers confirmed that the hypotensive effects can bring a significant problem in the elderly population because it can cause serious morbidity, such as falls or fractures. The two most common side effects are abnormal ejaculation (9.7% vs tamsulosin silodosin 1.0%) and dizziness (7.8% vs tamsulosin silodosin 2.9%). However, only two patients who decide to discontinue therapy silodosin.
Noting these results, dr. Yu concluded, "reasonable Silodosin viewed as an effective and safe therapy for patients with BPH."
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