Eszopiclone plus escitalopram for Patients Insomnia and Generalized Anxiety Disorder

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Provision of eszopiclone with escitalopram simultaneously improving the quality of sleep, daily activities, reduce anxiety, improve mood (atmosphere and the feeling) and well tolerated in patients with insomnia and GAD (Generalized Anxiety Disorder). This finding is the result of research conducted dr. Mark Pollack and colleagues from Massachusetts General Hospital, Boston, USA. The results of this study have also been published in the journal Archives of General Psychiatry.
Research conducted a double-blind study, randomized, placebo-controlled, parallel group, and involved patients aged 18-64 years who meet DSM IV-TR criteria for GAD and insomnia. Patients given 10 mg of
escitalopram for 10 weeks and were randomly assigned to therapy eszopiclone 3 mg (n = 294), or placebo (n = 301). In the last 2 weeks of the study, eszopiclone was replaced with placebo.
The results showed that when compared with escitalopram therapy plus placebo, eszopiclone plus escitalopram combination therapy result in improved quality of sleep and daily activities of significance (p <0.05). In addition patients treated with combination therapy has improved the HAM-A (Hamilton Anxiety Scale) per week (p <0.05), and CGI improvement (ClinicalGlobal Impressions) at each assessment (p <0.02). In patients treated with combination therapy, HAM-A response (63% vs. 49%, p = 0.001) and remission (42% vs. 36%, p = 0.09) at week 8 was higher in patients who diterpi with combination therapy of eszopiclone and escitalopram compared with placebo plus escitalopram. Time for Honest diperlukkan mean that the occurrence of anxiolytic response was also reduced significantly (p <0.05). After eszopiclone therapy is stopped, rebound insomnia is not the case. Meanwhile, differences in anxiety persisted. Overall adverse events occurred was 77.6% on combination therapy and 67.9% in the monotherapy group. Most side effects occur most often include headache, dry mouth, and sleepiness.
Experts in this study concluded that administration of eszopiclone and escitalopram combination therapy is effective in improving sleep, daytime activity, reduce anxiety and improve mood in patients with insomnia and GAD.

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