In animal studies the use of sevoflurane has shown protective effects against lung, as shown by the results in which sevoflurane reduce lung damage and can maintain lung function in acute lung injury.
W. Tiefenthaler and his colleagues have done one of these studies, and has been published in the British Journal of Anesthesia in 2010. The study was conducted to examine the effects of total intravenous anesthesia (TIVA or induction and maintenance of anesthesia with intravenous anesthetics) and balanced anesthesia (induction of anesthesia with intravenous anesthetics, maintenance of anesthesia with inhalation anesthetics) with sevoflurane on postoperative pulmonary function.
The study was conducted on 60 patients aged 21-60 years, who underwent elective lumbar disc surgery in the prone position. Patients were randomized to receive total intravenous anesthesia or balanced anesthesia (with fentanyl-N2O-sevoflurane). In the study, forced vital capacity (FVC), forced expiratory volume in 1 second, mid-expiratory flow (MEF 25-75) and expiratory flow peak was measured before and after general anesthesia.
The results showed that the parameters of lung function decline after surgery in both groups with a greater decline in FVC after total intravenous anesthesia than after balanced anesthesia with sevoflurane.
From the results of the study concludes that in patients who recovered unconscious from general anesthesia, decreased forced vital capacity greater postoperatively after total intravenous anesthesia (TIVA) than after the balanced anesthesia with sevoflurane.
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