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High levels of vitamin D in the blood appear to be associated with a reduced risk of incident diabetes in people at high risk for this disease, this is according to a recent report, presented Dr. Anastassios G. Pittas and colleagues from the division of endocrinology, diabetes, and metabolism, the Tufts New England Medical Center in Boston, Massachusetts which was presented at the American Diabetes Association 71st Scientific Sessions. According to Drs. Pittas, vitamin D may play a role in improving diabetes by increasing insulin secretion and insulin sensitivity, and most of the evidence focuses on the beneficial effects in pancreatic beta cells.
To determine the relationship between vitamin D status and risk of incident diabetes, the researchers analyzed data from the Diabetes Prevention Program (DPP), three groups of studies comparing intensive lifestyle
modification or metformin with placebo for the prevention of diabetes in patients with prediabetes. The average follow up of cohort studies with subjects as many as 2039 people was 3.2 years. Plasma levels of vitamin D were measured at yearly intervals, and incidence of diabetes.
Participants with vitamin D levels in the highest tertile (average concentration, 30.1 ng / mL) had a hazard ratio of 0.74 (95% [CI], 0.59 to 0.93) for diabetes, compared with those with vitamin D levels in the lowest tertile (average concentration, 12.8 ng / mL). The findings also showed the effects depend dosisyang indicated by levels of vitamin D; hazard ratio for incident diabetes was lowest (0.46, 95% CI, 0.23 to 0.90) in those with the highest levels of vitamin D (50 ng / mL or higher), compared with those with the lowest levels (below 12 ng / mL).
This study as a confirmation of an association between low vitamin D with risk of dibaetes, even after corrected weight factor.
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