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Citicoline, a natural substance that is found in brain and liver tissue that has been marketed as a nutritional supplement, improves cognition in healthy women and may have a role in reducing cognitive decline due to natural aging process, this is the latest research results. Citicoline is also expected to increase attention disorders associated with psychiatric disorders, said Erin McGlade, PhD, of the University of Utah Brain Institute, Salt Lake City, who led the study.
In his study, Dr. McGlade and colleagues involving as many as 60 women aged 40 to 60 years and they were screened to exclude psychiatric disorders axis 1 and 2, as well as any cognitive deficits beyond the cognitive
decline associated with aging. Further into 3 groups of subjects who were randomized to receive oral citicoline 250 mg (low dose) or 500 mg (high dose) per day or placebo for 28 days.
Next they evaluated by the Continuous Performance Test II (CPT-II) to measure the function of attention at the beginning and at the end of the study period. The researchers found that participants who received low-dose citicoline and high doses show increased attention, showing fewer errors and omissions on the CPT-II test compared with the placebo group.
In the study showed that citicoline supplementation for 28 days was significantly able to improve cognitive function as indicated by improvement of parameters of CPT-II, both with a dose of 250 mg per day or 500 mg per day.
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