Acetaminophen Long Term Use of Lower Prostate Cancer Risk

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Use of aspirin and NSAIDs (nonsteroidal anti-inflammatory drugs) long-term, is associated with a decreased risk of prostate cancer in some epidemiological studies. Research conducted by Eric Jacobs, Ph.D., an epidemiologist at the American Cancer Society led the research on long-term use of acetaminophen with prostate cancer incidence in 78,485 men (Cancer Prevention Study II Nutrition Cohort).
Information obtained by the use of acetaminophen using kuosioner completed at baseline in 1992 and updated using kuosioner follow-up in 1997 and every 2 years thereafter. During follow-up period from 1992
- 2007, there were 8092 prostate cancer incidence were identified. Regular use of acetaminophen (> 30 pills in a month) in the long term associated with a decreased risk of prostate cancer (RR = 0.62, 95% CI 0.44 to 0.87) and a malignant prostate cancer (RR = 0.49, 95% CI 0.27 to 0.88). Regular use of acetaminophen in <5 years is not associated with risk of prostate cancer.
Although the results of this observational study suggests that regular use of acetaminophen in long-term risks associated with lower prostate cancer. This finding requires a strengthening of the other studies, and do not justify the use of acetaminophen to prevent prostate cancer. Acetaminophen is an analgesic that is relatively safe when used according to the dosage recommendations, but an overdose of acetaminophen contribute greatly to the acute liver failure.
The results of this study can be used for further studies on acetaminophen and the process of developing prostate cancer and how it can inhibit this process.