Morphine sparing effect By Paracetamol

Acetaminophen or that we are familiar with Paracetamol is an analgesic antipyretic drug that is used to relieve pain and reduce fever. As an analgesic, paracetamol works by increasing the excitatory threshold of pain and as an antipyretic, suspected of working directly on the heat regulating center in the hypothalamus. Based on the guidelines of the WHO analgesic administration, in this case paracetamol, can be used on mild pain or moderate to severe pain when combined with opioid analgesics. Use of paracetamol in conjunction with opioid class of analgesics (morphine) can not only improve the effectiveness of analgesics but also can decrease the need for analgesic opioids (morphine) in moderate to severe pain, known by the name of the morphine sparing effect. Decline in demand is expected to decrease opioid side effects from the use of opioid analgesics group.

Meta-analysis by Remy et al (2005) conducted on seven prospective randomized studies with comparison, the number of patients with post-operative 265 in group acetaminophen (oral or intravenous) + morphine and 226 patients with morphine alone, showed that administration of acetaminophen reduces the need morphine (morphine sparing effect) by 20% (Average -9 mg; CI -15 to -3 mg, p <0.003). However, the results of this meta-analysis found no reduction in incidence of side effects of morphine morphine although demand has decreased.

In contrast to the results of a meta-analysis has been performed by Remy et al, the study by Young et al. (2011) of 76 women who underwent hysterectomy were randomly get 2 grams of intravenous premedication

Acetaminophen Long Term Use of Lower Prostate Cancer Risk

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Use of aspirin and NSAIDs (nonsteroidal anti-inflammatory drugs) long-term, is associated with a decreased risk of prostate cancer in some epidemiological studies. Research conducted by Eric Jacobs, Ph.D., an epidemiologist at the American Cancer Society led the research on long-term use of acetaminophen with prostate cancer incidence in 78,485 men (Cancer Prevention Study II Nutrition Cohort).
Information obtained by the use of acetaminophen using kuosioner completed at baseline in 1992 and updated using kuosioner follow-up in 1997 and every 2 years thereafter. During follow-up period from 1992