Gastroesophageal reflux disease (GERD) is a combination of spectrum-related disorders, including hiatal hernia, reflux disease with associated symptoms, erosive esophagitis, peptic strictures, Barrett esophagus, and esophageal adenocarcinoma. In addition to several pathophysiology and the relationship between some of these disorders, GERD is also characterized by the occurrence of identical co-morbidities and by the epidemiological behavior of similar patients.
Environmental risk factors in the etiology of GERD disease showed a marked and formed from temporal and geographical variations. Also variation by time, geography and race. Between 1975 and 2005, the incidence of GERD and esophageal adenocarcinoma has increased five-fold in most Western countries. The incidence