Increased EPC as a result of Citicoline with r-TPA

In patients with acute ischemic stroke increases in circulating endothelial progenitor cells (EPCs) is associated with better outcomes. CDP-choline (citicoline) enhance brain plasticity after stroke. This was revealed from the results of citicoline supplementation study conducted by Sobrino T, et al, published in Research in 2011 Neurolgical this.

Researchers define the EPC increase during the first week as the difference in the number of CFU-EC between day 7 and at the start of treatment. This is obtained by performing the study forty-eight patients with non-lacunar ischemic stroke is the first row is included in the study within 12 hours after the first attack. Patients received treatment with citicoline 2000 mg / day (n = 26) or received no treatment (placebo)